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It fights bacteria in your body. <li>Cotrimoxazole is used to treat infections such as urinary tract infections, bronchitis, ear infections (otitis), traveler's diarrhea, and Pneumocystis carinii pneumonia. <li>Cotrimoxazole may also be used for purposes other than those listed in this medication guide. </ul> <b>What should I discuss with my doctor before taking Cotrimoxazole? </b><ul> <li>Before taking this medication, tell your doctor if you have<ul> <li>kidney or liver disease, or <li>a glucose-6-phosphate dehydrogenase deficiency (G6PD deficiency). </ul> <li>You may not be able to take Cotrimoxazole, or you may require a lower dose or special monitoring during treatment if you have any of the conditions listed above. <li>Cotrimoxazole is in the FDA pregnancy category C. This means that it is not known whether sulfamethoxazole and trimethoprim will harm an unborn baby. Do not take the medication without first talking to your doctor if you are pregnant. <li>Cotrimoxazole passes into breast milk and may harm a nursing baby. Do not take it without first talking to your doctor if you are breast-feeding a baby. <li>Cotrimoxazole is not approved for use in children younger than 2 months of age. </ul> <b>How should I take sulfamethoxazole and trimethoprim? </b><ul> <li>Take this drug exactly as directed by your physician. If you do not understand these instructions, ask your pharmacist, nurse, or doctor to explain them to you. <li>Take each dose with a full glass of water. <li>Take it with food or milk if it upsets your stomach. <li>You may crush the tablets and put them in water or a soft food like applesauce or pudding if you cannot swallow them whole. <li>Take all of the Cotrimoxazole that has been prescribed for you even if you begin to feel better. 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